Mono Black Pox is the most widely used variant of Pox as it is both a budget-friendly Legacy deck and is a nostalgic deck for those who grew up playing older variations of the deck in the past, both in Extended and in Legacy.
As of now in 2023, Karn Pox is the most performing subtype of Mono Black Pox as it is the most versatile option for Pox, utilizes card selection, card advantage, and does a decent job closing games both by locking out the game with Karn, the Great Creator or winning via combat with Urza's Saga. Other variants include, but are not limited to is Bloodghast Pox, Ashiok Pox, and Legends Pox (most expensive variant of Mono Black Pox). All of which, while not the most performing, have their own merit that appeals to those who play them.
This is my Karn Pox deck that I play in paper and on MTGO blinged out.
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